Acute Cholecystitis is primarily caused by which of the following?

Acute cholecystitis is primarily caused by cystic duct obstruction, which usually occurs due to the presence of gallstones. When a gallstone moves into the cystic duct, it can block the flow of bile, leading to inflammation and swelling of the gallbladder. This obstruction causes increased pressure within the gallbladder and can result in a variety of symptoms, including pain in the upper right abdomen, nausea, vomiting, and fever.

While overeating fatty foods can contribute to the formation of gallstones, it is not the direct cause of acute cholecystitis itself. Similarly, infections can occur, but they typically arise as a complication rather than an initial cause. Finally, while there may be a genetic predisposition to developing gallstones and cholecystitis, it is not the primary factor leading to the acute inflammation observed in cases of acute cholecystitis. Therefore, the blockage of the cystic duct is the key factor triggering this condition.