High levels of HCl in Zollinger-Ellison syndrome can lead to what condition?

In Zollinger-Ellison syndrome, the pancreas secretes excessive amounts of gastrin, a hormone that stimulates the production of gastric acid (HCl) in the stomach. This overproduction of HCl can lead to severe abdominal pain, primarily due to the development of peptic ulcers, which are erosions in the stomach lining or the first part of the small intestine. The high acidity can damage the gastrointestinal mucosa, causing irritation and inflammation, ultimately leading to significant discomfort and pain.

Additionally, the ulcers can cause complications like gastrointestinal bleeding or perforation, exacerbating the abdominal pain experienced by the patient. This relationship between increased gastric acidity and abdominal pain is a well-documented aspect of Zollinger-Ellison syndrome, making severe abdominal pain the most direct and relevant consequence of the condition.