Substance P is secreted alongside which neurotransmitter?

Substance P is a neuropeptide that plays a significant role in transmitting pain and other sensory signals in the nervous system. It is commonly released in conjunction with acetylcholine, particularly in certain types of neurons, including those involved in the transmission of pain and inflammatory responses. The co-release of substance P and acetylcholine is particularly relevant in the context of spinal cord neurons and certain peripheral systems, where they work together to facilitate signaling related to pain perception. This relationship is crucial for understanding how pain pathways operate and the role of neurotransmitters in these processes.

The other neurotransmitters listed do not typically co-secrete with substance P in the same physiological contexts, making the pairing with acetylcholine the most relevant and recognized association in both central and peripheral nervous systems.