What is the primary function of GLUT2 in the body?

GLUT2 is primarily known for its role as a glucose transporter, particularly in specific tissues where it facilitates the transport of glucose from the intestinal epithelium into the bloodstream. After carbohydrates are digested, glucose is absorbed by the epithelial cells of the intestine, and GLUT2 then allows this glucose to exit the cells and enter the bloodstream. This function is crucial for maintaining glucose homeostasis, especially postprandially (after eating), as it helps regulate blood sugar levels.

In addition to its role in the intestine, GLUT2 is also found in the liver, pancreas, and kidneys, where it helps in glucose sensing and regulation, contributing to overall metabolic processes. Thus, its primary function revolves around the transport of glucose, making it vital for energy balance and metabolic health.