Which digestive hormone has a mild inhibitory effect on GI motility?

The hormone with a mild inhibitory effect on gastrointestinal (GI) motility is secretin. Secretin is primarily released by S cells in the duodenum in response to acidic chyme entering from the stomach. Its main role is to regulate the pH of the intestinal environment by stimulating the pancreas to secrete bicarbonate-rich fluid, which helps neutralize stomach acid.

While secretin's primary function is related to acid neutralization and enzyme regulation, it also has a mild inhibitory effect on gastric motility, slowing down the movement of food through the stomach and into the intestines. This helps ensure that the digestive process operates smoothly and that the intestinal lining is not overwhelmed by acidic contents, allowing for proper digestion and absorption.

This context makes secretin an integral part of the regulatory mechanisms of digestion, balancing motility and secretion in the GI tract.