Which of the following factors can lead to hepatitis?

Hepatitis is an inflammation of the liver that can result from various factors, including long-term drug or alcohol use. Chronic abuse of alcohol can lead to alcoholic hepatitis, while certain drugs can also cause toxicity to liver cells, leading to inflammation. Prolonged exposure to these substances can disrupt liver function and promote inflammatory processes, contributing to the overall condition of hepatitis.

Other options, while they might seem related to liver health, do not typically cause hepatitis directly. Viral infections are a common cause of hepatitis but are not the only factor, making the first choice too restrictive. Excessive exercise generally does not lead to liver inflammation, and a high fiber diet is considered beneficial for overall health, including liver function. Therefore, the most accurate choice regarding a direct cause of hepatitis is long-term drug or alcohol use.