Which type of cells in the fundus of the stomach secrete intrinsic factor?

Intrinsic factor is a critical glycoprotein that is secreted by parietal cells located in the fundus of the stomach. Its primary function is to bind to vitamin B12, enabling its absorption in the ileum of the small intestine. This binding is essential because vitamin B12 is vital for red blood cell formation, neurological function, and DNA synthesis.

Parietal cells are characterized by their ability to produce hydrochloric acid as well, which plays a crucial role in digestion and creates an acidic environment that activates digestive enzymes. The secretion of intrinsic factor is specifically associated with the parietal cells, distinguishing them from other types of gastric cells, such as chief cells, which produce digestive enzymes, and G cells, which are responsible for secreting the hormone gastrin. Goblet cells, on the other hand, primarily secrete mucus and are not involved in intrinsic factor production.