Zollinger-Ellison syndrome is associated with cancer in which organs?

Zollinger-Ellison syndrome is characterized by the development of gastrin-secreting tumors, known as gastrinomas, which primarily occur in the pancreas or the duodenum. These tumors lead to excessive production of gastric acid, causing recurrent peptic ulcers and other gastrointestinal symptoms. The pancreas is often the site of gastrinoma, while the duodenum can also harbor these tumors due to its proximity.

This condition is significant because gastrinomas can be malignant and may spread to lymph nodes or other organs, but their primary locations are indeed the pancreas and the duodenum. This understanding of gastrinomas and their association with the gastrointestinal system is critical, making the identification of these organs the correct choice in relation to Zollinger-Ellison syndrome.