Zollinger-Ellison Syndrome is related to increased secretion of which substance?

Zollinger-Ellison Syndrome is characterized by the presence of gastrin-secreting tumors, known as gastrinomas, typically located in the pancreas or the duodenum. The hallmark of this syndrome is the excessive secretion of gastrin, which subsequently leads to increased production of hydrochloric acid (H+) in the stomach. This results in recurrent peptic ulcers due to the elevated acidity in the gastric environment. The condition causes the stomach to produce more acid than normal and can significantly impact the digestive system, leading to complications such as diarrhea and malabsorption. Therefore, recognizing the connection between gastrin and H+ secretion is crucial for understanding the underlying pathology of Zollinger-Ellison Syndrome.